The Orioles welcomed the Yankees to Camden Yards on Friday for their final series of the season under vastly different circumstances than normal.

Baltimore is atop the American League East, while New York is in its cellar. Friday’s rain-delayed contest didn’t display the disparity between the clubs — that is, until Anthony Santander stepped to the plate in the ninth inning.

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With the game scoreless, Santander sent the announced crowd of 34,558 home with a walk-off home run to right field. The switch-hitter clobbered a 2-0 changeup from Yankees reliever Tommy Kahnle 425 feet for the Orioles’ fifth walk-off win of the season.

Before Santander’s solo shot — his second walk-off homer and third walk-off hit of his career — the AL East matchup was a pitcher’s duel between Orioles rookie Grayson Rodriguez and Yankees ace Gerrit Cole. Both bullpens followed to keep the game scoreless until Santander’s 18th home run of the season.

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Baltimore is 63-40 and remains 1 1/2 games up on the Tampa Bay Rays atop the AL East. The Orioles are nine games ahead of the Yankees.

The Orioles' Anthony Santander (25) celebrates at home plate after his walk-off home run against the New York Yankees in the ninth inning Friday.

Pitching opposite Cole was nothing new for Rodriguez.

In more starts than not, the 23-year-old rookie has gone up against a top-line starting pitcher, including Jacob deGrom, Dylan Cease, Eduardo Rodriguez, Shohei Ohtani and Shane McClanahan.

On Friday, he matched Cole pitch for pitch, out for out, inning for inning. Both right-handers — the Yankees’ a six-time All-Star, the Orioles’ pitching in his 13th MLB game — held the opposing lineup to three hits.

There are several encouraging signs from Rodriguez’s start, but none more so than his strike total. Seventy of his 97 pitches — 72.2% — went for strikes. Nearly 60% of his pitches were fastballs, a pitch that generated eight swings and misses. He averaged 98.3 mph with the pitch, including topping 100 mph four times in the first two innings. Command and confidence in his fastball were the main improvements the Orioles wanted to see Rodriguez make when they optioned him to Triple-A in late May after he posted a 7.35 ERA in his first 10 starts.

Orioles starting pitcher Grayson Rodriguez allowed three hits in 6 1/2 shutout innings as he pitched into the seventh for the first time in his major league career.

Rodriguez’s efficiency is what allowed him to complete six innings — and pitch into the seventh — for the first time in his nascent big league career. He retired the first 10 batters he faced, escaped a jam in the fourth with a double play, stranded a base runner in the fifth and won an 11-pitch battle with No. 3 hitter Anthony Rizzo to end the sixth.

After allowing a one-out single to DJ LeMahieu, Rodriguez was pulled for newly acquired right-hander Shintaro Fujinami, who walked his first batter before inducing an inning-ending double play. Fujinami, who the Orioles acquired from the Oakland Athletics last week, struggled in his first two outings but has been effective in his past two.

The scoreless start was the third of Rodriguez’s career. In three starts since returning from Triple-A Norfolk, the 6-foot-5 righty has a 3.18 ERA, allowing 13 hits in 17 innings.

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Mike Elias began his pre-trade deadline news conference Friday with a bevy of updates about the seven Orioles on the injured list: center fielder Cedric Mullins (right adductor groin strain, 10-day IL), outfielder Aaron Hicks (left hamstring strain, 10-day), starting pitcher John Means (Tommy John elbow reconstruction surgery recovery, 60-day), reliever Mychal Givens (right shoulder inflammation, 60-day), right-hander Dillon Tate (elbow flexor strain, 60-day), left-hander Keegan Akin (lower back discomfort, 15-day) and right-hander Austin Voth (elbow discomfort, 15-day).

Baltimore’s executive vice president and general manager said the “hope” for Mullins and Hicks is that they’ll play a “large bit of August” with the Orioles. The groin strain is Mullins’ second; he missed about a month the first time he was out, and Hicks filled in with aplomb after coming over from the Yankees.

Means, the Orioles’ opening day starter in 2021 and 2022, could begin his minor league rehabilitation assignment in the Florida Complex League in early August. Elias said early September is the goal for Means’ return to the majors, but in what role remains unclear.

“I think it’s going to depend on so much that I don’t have right now,” he said. “Obviously he’s a starting pitcher as far as a career standpoint and a skill standpoint, but the circumstances of the team and him will drive that decision.”

Givens and Akin are also on track to begin their rehab assignments in early August. Voth, who has pitched three times since beginning his assignment July 20, still has “a bit more” to go before he’ll be ready to return to the Orioles’ bullpen, if there’s space after the acquisition of Fujinami last week.

The only pitcher Elias didn’t have any sort of timeline on was Tate, who isn’t throwing yet as he’s managed a forearm injury all season and has yet to pitch in the majors. Elias said the Orioles “still have hopes” of Tate pitching for them before the end of the regular season.

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Elias also provided an update on left-handed pitching prospect DL Hall, who last month went to the team’s facility in Sarasota, Florida, to focus on strength training and pitch less with the hope of getting his velocity back. He said Hall, who pitched in an FCL game Tuesday, is up a few ticks to the mid-90s mph range.

Like Means, Elias said the organization isn’t sure if they’ll build Hall up to be a starter again or if they’ll focus on shorter outings, perhaps to have him join the Orioles’ bullpen late in the season.

“I think he’s in a better spot than where he started and he’s very healthy and he’s also very fresh for the second half, so that might be nice,” Elias said.

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Friday was “Mo Gaba Day” at Camden Yards on the third anniversary of Gaba’s death. Gaba’s mother, Sonsy, threw out the first pitch, caught by former Orioles outfielder Adam Jones.

Jones also spent part of the contest in Section 86, known as the Bird Bath Splash Zone, as the first “guest splasher” of the season. The former center fielder had a custom City Connect jersey with “Capt Splash” on the back. He sprayed fans with water and pied Mr. Splash as Jones often did during postgame celebrations.

This story will be updated.

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